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Dead Sea Scrolls “Puzzle” Pieced Using DNA Extracted from the Animal Skins on which the Scrolls Were

TRANSGENERATIONAL SMALL RNA INHERITANCE

THE NEURONAL BASIS FOR DECISION-MAKING - WHAT LEADS TO IRRATIONALITY?

Publications

Trans-regenerational RNAi Memory in Planarians
Prakash V. Cherian, Idit Aviram, Uri Weill, Tamar Shapira, Sarit Anava, Hila Gingold, Jochen C. Rink, Oded Rechavi, Omri Wurtzel bioRxiv 2026
Scavenger Cells Failure to Maintain Systemic RNA Homeostasis Causes Epigenetically Inherited Germline Tumors Itai Rieger, Yael Mor, Itamar Lev, Anat Nitzan, Charlotte Beata Kong, Sarit Anava, Hila Gingold, Ronen Zaidel-Bar, Oded Rechavi bioRxiv 2026
Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans.
Landschaft-Berliner D, Goldstein K, Teichman G, Anava S, Gingold H, Salzberg Y, Rieger I, Levy N, Pechuk V, Setty H, Agarwal P, Sagi D, Cohen D, Nikelshparg E, Ben-Zvi A, Miranda-Vizuete A, Zaidel-Bar R, Oren-Suissa M, Rechavi O. Nat Neurosci. 2026.
S. Bracha, H. J. Johnson, N. A. Pranckevicius , F. Catto, A. E. Economides, S. Litvinov, K. Hassi, M. Tullio Rigoli, C. Cheroni, M. Bonfanti, A. Valenti , S. Stucchi, S. Attreya, P. D. Ross, D. Walsh, N. Malachi, H. Livne, R. Eshel, V. Krupalnik, D. Levin, S. Cobb, P. Koumoutsakos, N. Caporale, G. Testa, A. Aguzzi, A. A.Koshy, L. Sheiner, O. Rechavi. Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nature Microbiology, 2024.
I. Rieger, G. Weintraub, I. Lev, K. Goldstein, D. Bar-Zvi, S. Anava, H. Gingold, S. Shaham, O. Rechavi. Nucleus-Independent Transgenerational Small RNA Inheritance in C. elegans. Science Advances, 2023.
I. Toker, I. Lev, Y. Mor, Y. Gurevich, D. Fisher, L. Houri-Zeevi, O. Antonova, L. Hadany, S. Shaham, O. Rechavi. Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans. Developmental Cell, 2022.
L. Houri-Ze’evi, G. Teichman, H. Gingold, O. Rechavi. “Stress Resets Ancestral Heritable Small RNA Responses". eLife, 2021.
R. Posner*, I.A. Toker*, O. Antonova, E. Star, S. Anava, E. Azmon, M. Hendricks, S. Bracha, H. Gingold, O. Rechavi. Neuronal Small RNAs Control Behavior Transgenerationally. Cell, 2019.
I. Lev*, I.A. Toker*, Y. Mor*, A. Nitzan, G. Weintraub, O. Antonova, O. Bhonkar, I. Ben Shushan, U. Seroussi, J.M. Claycomb, S. Anava, H. Gingold, R. Zaidel-Bar, O. Rechavi. Germ Granules Govern Small RNA Inheritance. Current Biology, 2019.
S. Anava, M. Neuhof, H. Gingold, O. Sagy, A. Munters, E. M.Svensson, E. Afshinnekoo, D. Danko, J. Foox, P. Shor, B. Riestra, D. Huchon, C.E. Mason, N. Mizrahi, M. Jakobsson, O. Rechavi. Illuminating Genetic, Mysteries of the Dead Sea Scrolls. Cell, 2020.
O.Rechavi, L. Houri-Ze'evi, S. Anava, W.S. Sho Goh, S.Y. Kerk, G.J. Hannon, O. Hobert. Starvation-induced transgenerational inheritance of small RNAs in C. elegans. Cell, 2014.

Trans-regenerational RNAi Memory in Planarians
Prakash V. Cherian, Idit Aviram, Uri Weill, Tamar Shapira, Sarit Anava, Hila Gingold, Jochen C. Rink, Oded Rechavi, Omri Wurtzel bioRxiv 2026
Scavenger Cells Failure to Maintain Systemic RNA Homeostasis Causes Epigenetically Inherited Germline Tumors Itai Rieger, Yael Mor, Itamar Lev, Anat Nitzan, Charlotte Beata Kong, Sarit Anava, Hila Gingold, Ronen Zaidel-Bar, Oded Rechavi bioRxiv 2026
How do authors want to use AI for review? : A survey to assess the perception of scientists who received both AI and human reviews of their manuscripts.
Lemberger T, Mastboim NS, Rechavi O. EMBO Rep. 2026
Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans.
Landschaft-Berliner D, Goldstein K, Teichman G, Anava S, Gingold H, Salzberg Y, Rieger I, Levy N, Pechuk V, Setty H, Agarwal P, Sagi D, Cohen D, Nikelshparg E, Ben-Zvi A, Miranda-Vizuete A, Zaidel-Bar R, Oren-Suissa M, Rechavi O. Nat Neurosci. 2026.
CK. Ewe, G. Teichman, S. Weiss, M.M.L. Knott. S. Anava, H. Gingold, M.B. Sarmiento, E. Troemel. O. Rechavi. Dynamic control of Argonautes by a rapidly evolving immunological switch. Current Biology, 2025.
R. Haque, S. P. Kurien, H. Setty, Y. Salzberg, G. Stelzer, E. Litvak, H. Gingold, O. Rechavi, M. Oren-Suissa. Sex-Specific Developmental Gene Expression Atlas Unveils Dimorphic Gene Networks in C. elegans, Nature Communication, 2024.
M.M.L. Knott, O. Rechavi. Transgenerational inheritance of engineered cytosine methylation in mice. Cell Research, 2023.
O. Rechavi, P Tomancak. Who did what: changing how science papers are written to detail author contributions. Nature Reviews in Molecular Cell Biology, 2023
Y. Yovel, O. Rechavi. AI and the Doctor Dolittle challenge. Current Biology, 2023.
CK. Ewe, O. Rechavi. The third barrier to transgenerational inheritance in animals: somatic epigenetic resetting. EMBO Rep, 2023.
F. Bernard, D. Dargère, O. Rechavi, D. Dupuy. Quantitative analysis of C. elegans transcripts by Nanopore direct-cDNA sequencing reveals terminal hairpins in non-trans-spliced mRNAs. Nature Communication, 2023.
G. Teichman, D. Cohen, O. Ganon, N. Dunsky, S. Shani, H. Gingold, O. Rechavi. RNAlysis: analyze your RNA sequencing data without writing a single line of code. BMC Biol, 2023.
X. Chen, O. Rechavi. Plant and animal small RNA communications between cells and organisms. Nature Reviews in Molecular Cell Biology, 2022.
O. Rechavi. Re-evaluate evaluation letters — set scientists free! Nature Reviews in Molecular Cell Biology, 2022.
S. Uszkoreit, D. H. Meyer, O. Rechavi, B. Schumacher, Sensory neurons safeguard from mutational inheritance by controlling the CEP-1/p53-mediated DNA damage response in primordial germ cells. bioRxiv, 2022.
I. Rieger, and O. Rechavi. ZNFX-1 keeps RNAi in the loop. Developmental Cell, 2022
Eric A. Miska and O. Rechavi. “Can Brain Activity Transmit Transgenerationally?”: Nematode Models of Development and Disease. Current Topics in Developmental Biology, 2021.
O. Rechavi. Transgenerational Inheritance: That Pathogen Gut Feeling. Current Biology, 2020.
L. Houri-Ze’evi*, Y. Korem-Kohanim, O. Antonova, O. Rechavi. Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans. Cell, 2020.
H. Ishtayeh, H. Achache, E. Kroizer, Y. Rappaport, E. Itskovits, H. Gingold, C. Best, O. Rechavi, Y.B. Tzur. Systematic analysis of long intergenic non-coding RNAs in C. elegans germline uncovers roles in somatic growth. RNA Biology, 2020.
I. Lev, O. Rechavi. Germ Granules Allow Transmission of Small RNA-Based Parental Responses in the “Germ Plasm”. iScience, 2020.
D. Cohen*, G. Teichman*, M. Volovich, Y. Zeevi, L. Elbaum, A. Madar, K. Louie, D.J. Levy, O. Rechavi. Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways. Nature Communications, 2019.
I. Lev, H. Gingold, O. Rechavi. H3K9me3 is Required for Inheritance of Small RNAs that Target a Unique Subset of Newly Evolved Genes. eLife 2019.
A. Hakim, Y. Mor, I.A. Toker, A. Levine, M. Neuhof, Y. Markovitz, O. Rechavi. WorMachine: Machine Learning-Based Phenotypic Analysis Tool for Worms. BMC Biology, 2018.
A.Agorio, S.Durand, E.Fiume, C.Brousse, I.Gy, M.Simon, S.Anava, O.Rechavi, O.Loudet, C.Camilleri, N.Bouché. An Arabidopsis Natural Epiallele Maintained by a Feed-Forward Silencing Loop between Histone and DNA. PLoS Genetics, 2017.
L. Morgado, V. Preite, C. Oplaat, S. Anava, J. Ferreira de Carvalho, O. Rechavi, J.F. Johannes, K. Verhoeven. Small RNAs reflect grandparental environments in apomictic dandelion. Molecular Biology and Evolution, 2017.
M. Bar, B. Rotblat, O. Rechavi. Nomad Scientists and the Ones Left Behind. eLife, 2017.
O. Rechavi, I. Lev. Principles of Transgenerational Small RNA Inheritance in C. elegans. Current Biology, 2017.
L. Houri-Ze’evi, O. Rechavi. A Matter of Time: Small RNAs Regulate the Duration of Epigenetic Inheritance. Trends in Genetics, 2017.
I. Lev, U. Seroussi, H. Gingold, R. Bril, S. Anava, O. Rechavi. MET-2-Dependent H3K9 Methylation Suppresses Transgenerational Small RNA Inheritance. Current Biology, 2017.
D. Sagi, R .Rak, H. Gingold, I. Adir, G. Maayan, O. Dahan, I. Pilpel, O. Rechavi, Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes. PLoS Genetics, 2016.
M. Neuhof, M .Levin, O. Rechavi. Vertically and horizontally transmitted memories – the fading boundaries between regeneration and inheritance in Planaria. Biology Open, 2016.
L. Houri-Ze’evi, O. Rechavi. Plastic Germline Reprogramming of Heritable Small RNAs Enables Maintenance or Erasure of Epigenetic Memories. RNA Biology, 2016.
L. Houri-Ze’evi, Y. Korem, H. Sheftel, L. Faigenbloom, I. Toker, Y. Dagan, L. Awad, L. Dagani, U. Alon, O.Rechavi. A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans. Cell, 2016.
N. Rainy, M. Zayoud, Y. Kloog, O. Rechavi, I. Goldstein. Viral oncomiR spreading between B and T cells is employed by kaposi's sarcoma herpesvirus to induce non-cell-autonomous target gene regulation. Oncotarget, 2016.
Y. Pilpel, O. Rechavi. The Lamarckian Chicken and Darwinian Egg. Biology Direct, 2015.
O. Rechavi. Guest list or Black list: Heritable small RNAs as immunogenic memories. Trends in Cell Biology, 2014.
S. Anava, R. Posner, O. Rechavi. The Soft Genome. Worm, 2014.
O. Sagy, R. Shamir, O. Rechavi. Examination of exhaustive cloning attempts reveals that C. elegans piRNAs, transposons, and repeat sequences are efficiently cloned in yeast, but not in bacteria. Frontiers in Genetics, 2014.
M. Sela, Y. Kloog, O. Rechavi. Non-coding RNAs as the bridge between epigenetic mechanisms, lineages, and domains of life. Journal of Physiology, 2014.
H. Vernitsky, O. Rechavi, N. Rainy, M.J. Besser, M. Nagar, J. Schachter, Y. Lerenthal, M. Ehrlich, Y. Kloog, I. Goldstein. Ras Oncoproteins Transfer from Melanoma Cells to T Cells and Modulate Their Effector Functions. Journal of Immunology, 2012.
N. Rainy, D. Chetrit, V. Rouger, H. Vernitsky, O. Rechavi, D. Marguet, I. Goldstein, M. Ehrlich, Y. Kloog. H-Ras Transfers from B to T Cells via Tunneling Nanotubes. Cell Death & Disease, 2013.
O. Rechavi, G. Minevich, O. Hobert. Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans. Cell, 2011.
O. Rechavi, M. Kalman, Y. Fang, H. Vernitsky, J. Jacob-Hirsch, L.J. Foster, Y. Kloog, I. Goldstein. Trans-SILAC: sorting out the non-cell-autonomous proteome. Nature Methods, 2010.
O. Rechavi, Y. Kloog. Prion and Anti-Codon Usage: Does Infectious PrP Alter tRNA Abundance to Induce Misfolding of PrP? Medical Hypotheses, 2009.
O. Rechavi*, Y. Erlich*, H. Amram*, L. Flomenblit, F.V. Karginov, I. Goldstein, G.J. Hannon, Y. Kloog. Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs. Genes & Development, 2009.
O. Rechavi, I. Goldstein, Y. Kloog. Intercellular Exchange of Proteins: The Immune Cell Habit of Sharing. FEBS Letters, 2009.
O. Rechavi*, I. Goldstein*, H. Vernitsky, B. Rotblat, and Y. Kloog. Intercellular Transfer of Oncogenic H-Ras at the Immunological Synapse. PLoS ONE, 2007.

Research Tools

WorMachine

Machine Learning-Based Phenotypic Analysis Tool for Worms.

A three-step MATLAB-based image analysis software developed in the Rechavi Lab that allows automated identification of C. elegans worms, extraction of morphological features, and quantification of fluorescent signals.

Visit WorMachine

RNAlysis

RNAlysis is a modular Python-based analysis software for RNA sequencing data that was developed in the Oded Rechavi Lab.

RNAlysis allows users to build customized analysis pipelines suiting their specific research questions, going all the way from raw FASTQ files, through exploratory data analysis and data visualization, clustering analysis, and gene-set enrichment analysis. RNAlysis provides a friendly graphical user interface, allowing researchers to analyze data without writing code.

Visit RNAlysis

Funding

Research

Research Blog

"Can't start a fire without a spark"

Dead Sea Scrolls “Puzzle” Pieced Using DNA Extracted from the Animal Skins on which the Scrolls Were

TRANSGENERATIONAL SMALL RNA INHERITANCE

THE NEURONAL BASIS FOR DECISION-MAKING - WHAT LEADS TO IRRATIONALITY?

Publications

Research Tools

WorMachine

Machine Learning-Based Phenotypic Analysis Tool for Worms. A three-step MATLAB-based image analysis software developed in the Rechavi Lab that allows automated identification of C. elegans worms, extraction of morphological features, and quantification of fluorescent signals. Visit WorMachine

RNAlysis

Funding

Machine Learning-Based Phenotypic Analysis Tool for Worms.

A three-step MATLAB-based image analysis software developed in the Rechavi Lab that allows automated identification of C. elegans worms, extraction of morphological features, and quantification of fluorescent signals.

Visit WorMachine