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Laboratory for radical science


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Laboratory for radical science


The rechavi lab

In our lab we challenge basic dogmas regarding inheritance and evolution, using simple powerful genetic model organisms. In particular, using nematodes, we have shown that exposure to different challenges triggers the synthesis of heritable small RNAs which regulate genes in the progeny, resulting in phenotypic changes several generations down the road. In addition to studying epigenetic inheritance, we are developing useful parasites, investigating the neuronal basis of rational decision-making, and try to do as many crazy experiments as possible.

We focus our studies mostly, but not exclusively, on C.elegans nematodes, wonderful creatures that we find irresistible. C.elegans has a super-short generation time of just 3 days, and its nervous system is composed of just 302 neurons (and the entire “connectome” is mapped). These properties, combined with awesome genetic tools and unparalleled ease of cultivation, make the worm the ideal model organism for studying memory, and in particular heritable memory. Nevertheless, we are aware that other organisms have feelings too, and therefore try to make our studies as relevant as possible, so no one is offended. We currently study also toxoplasma parasites, and planaria flatworms, but there are often other weird animals running around the lab.

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The Kitchen


The Kitchen


                   

ODED “pretzel” RECHAVI

Associate Professor

odedrechavi[at]gmail.com

Curriculum Vitae

SARIT ANAVA

Lab Manager

saritan78[at]gmail.com

Lab Members

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RESEARCH


"Can't start a fire without a spark"
Bruce Springsteen

RESEARCH


"Can't start a fire without a spark"
Bruce Springsteen

 

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The Zoo


The Zoo


Everything connects in the end!

We try very hard to let our curiosity guide us, and when the muse calls, we don’t get in its way. Because of that, we find ourselves studying many diverge subjects, including the mechanisms that allow toxoplasma parasites to control its host, translational read through, Pol III regulatory mechanisms, Ancient DNA, Fertility, Helmet formation in Daphnia, genome rearrangement in ciliates, polyploidy, development of new optogeneic tools,machine learning algorithms for automated phenotyping and decision making.

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Selected Publications


Selected Publications


Posner R#, Toker IA#, Antonova O, Star E, Anava S, Azmon E, Hendricks M, Bracha S, Gingold H, Rechavi O. (2019) Neuronal Small RNAs Control Behavior Transgenerationally. Cell. 
# Equal contribution
In the media: Haaretz, Ynet.
See the F1000 and The Scientist Highlights

Lev I#, Toker IA#, Mor Y#, Nitzan A, Weintraub G, Antonova O, Bhonkar O, Ben Shushan I, Seroussi U, Claycomb JM, Anava S, Gingold H, Zaidel-Bar R, Rechavi O. (2019) Germ Granules Govern Small RNA Inheritance. Current biology. pre-print: bioRxiv.
# Equal contribution

Bracha S, Hassi K, Ross P.D., Cobb S, Sheiner L, Rechavi O. Engineering Brain Parasites for Intracellular Delivery of Therapeutic Proteins. pre-print: bioRxiv.

Lev I, Gingold H, Rechavi O. (2018) H3K9me3 is Required for Inheritance of Small RNAs that Target a Unique Subset of Newly Evolved Genes. eLife.

Cohen D#, Teichman G#, Volovich M, Zeevi Y, Elbaum L, Madar A, Louie K, Levy DJ, Rechavi O. (2019) Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways. Nature Comm (in press). pre-print: bioRxiv.
# Equal contribution

Hakimi A#, Mor Y#, Toker IA, Levine A, Markovitz Y, Rechavi O. (2017) WorMachine: Machine Learning-Based Phenotypic Analysis Tool for Worms. BMC Biology.  
# Equal contribution

Rechavi O. Lev I. (2017) Principles of Transgenerational Small RNA Inheritance in C. elegansCurrent Biology.

Bar M, Rotblat B, Rechavi O. (2017). Nomad scientists and the ones left behind. eLife.

Lev I#, Seroussi U#, Gingold H, Bril R, Anava S, *Rechavi O. (2017). MET-2-Dependent H3K9 Methylation Suppresses Transgenerational Small RNA Inheritance. Current Biology.
# Equal contribution
See the dispatch review on the paper in Current Biology

*Houri-Ze'evi L, Korem Y, Sheftel H, Faigenbloom L, Toker IA, Dagan Y, Awad L, Degani L, Alon U, Rechavi O. (2016). A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans. Cell.

See the review in Nature Reviews Genetics

Houri-Ze'evi L, Rechavi O (2016). A Matter of Time: Small RNAs Regulate the Duration of Epigenetic Inheritance. Trends in Genetics.

Sagi D, Rak R, Gingold H, Adir I, Maayan G, Dahan O, Broday L, Pilpel Y, Rechavi O. (2016). Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes. PLoS Genet.

*Rechavi, O., Houri-Ze’evi, L., Anava, S., Goh, WS., Kerk, SY., Hannon, GJ., and Hobert, O.(2014). Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans. Cell. 

See also Leading Edge Commentary in Cell 

Rechavi, O. (2013). Guest list or black list: heritable small RNAs as immunogenic memories‏. Trends in Cell Biology. 

*Rechavi, O., Minevich, G., and Hobert, O. (2011). Transgenerational inheritance of an acquired small RNA-based antiviral response in C.elegans. Cell. 147, 1248 1256. 

See the F1000 Highlight

Rechavi, O., Kalman, M., Fang, Y., Vernitsky, H., Jacob-Hirsch, J., Foster, L. J., Kloog, Y., and Goldstein, I. (2010). Trans-SILAC: sorting out the non-cell-autonomous proteome. Nature Methods. 7:923-927. 

Rechavi, O., Erlich, Y., Amram, H., Flomenblit, L., Karginov, F. V., Goldstein, I, Hannon, G. J., and Kloog, Y. (2009). Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs. Genes & Development. 23:1971-1979.

* Corresponding author

 

 

Resources


Resources


 
 
 
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WorMachine: Machine Learning-Based Phenotypic Analysis Tool for Worms

A three-step MATLAB-based image analysis software developed in the Rechavi Lab that allows automated identification of C. elegans worms, extraction of morphological features, and quantification of fluorescent signals.


Planaria


Planaria


 
M Neuhof, M Levin, O Rechavi. (2016).  Vertically- and horizontally-transmitted memories – the fading boundaries between regeneration and inheritance in planaria.  Biology Open

M Neuhof, M Levin, O Rechavi. (2016). Vertically- and horizontally-transmitted memories – the fading boundaries between regeneration and inheritance in planaria. Biology Open

 
 
 

Funding


Funding


 
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In the media


In the media


Gallery


Gallery