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RESEARCH


"Can't start a fire without a spark"
Bruce Springsteen

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RESEARCH


"Can't start a fire without a spark"
Bruce Springsteen

 

2014-11-13-quill.jpg

Selected Publications


Selected Publications


Posner R#, Toker IA#, Antonova O, Star E, Anava S, Azmon E, Hendricks M, Bracha S, Gingold H, Rechavi O. (2019) Neuronal Small RNAs Control Behavior Transgenerationally. Cell. 
# Equal contribution
In the media: Haaretz, Ynet.
See the F1000 and The Scientist Highlights

Lev I#, Toker IA#, Mor Y#, Nitzan A, Weintraub G, Antonova O, Bhonkar O, Ben Shushan I, Seroussi U, Claycomb JM, Anava S, Gingold H, Zaidel-Bar R, Rechavi O. (2019) Germ Granules Govern Small RNA Inheritance. Current biology. pre-print: bioRxiv.
# Equal contribution

Bracha S, Hassi K, Ross P.D., Cobb S, Sheiner L, Rechavi O. Engineering Brain Parasites for Intracellular Delivery of Therapeutic Proteins. pre-print: bioRxiv.

Lev I, Gingold H, Rechavi O. (2018) H3K9me3 is Required for Inheritance of Small RNAs that Target a Unique Subset of Newly Evolved Genes. eLife.

Cohen D#, Teichman G#, Volovich M, Zeevi Y, Elbaum L, Madar A, Louie K, Levy DJ, Rechavi O. (2019) Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways. Nature Comm (in press). pre-print: bioRxiv.
# Equal contribution

Hakimi A#, Mor Y#, Toker IA, Levine A, Markovitz Y, Rechavi O. (2017) WorMachine: Machine Learning-Based Phenotypic Analysis Tool for Worms. BMC Biology.  
# Equal contribution

Rechavi O. Lev I. (2017) Principles of Transgenerational Small RNA Inheritance in C. elegansCurrent Biology.

Bar M, Rotblat B, Rechavi O. (2017). Nomad scientists and the ones left behind. eLife.

Lev I#, Seroussi U#, Gingold H, Bril R, Anava S, *Rechavi O. (2017). MET-2-Dependent H3K9 Methylation Suppresses Transgenerational Small RNA Inheritance. Current Biology.
# Equal contribution
See the dispatch review on the paper in Current Biology

*Houri-Ze'evi L, Korem Y, Sheftel H, Faigenbloom L, Toker IA, Dagan Y, Awad L, Degani L, Alon U, Rechavi O. (2016). A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans. Cell.

See the review in Nature Reviews Genetics

Houri-Ze'evi L, Rechavi O (2016). A Matter of Time: Small RNAs Regulate the Duration of Epigenetic Inheritance. Trends in Genetics.

Sagi D, Rak R, Gingold H, Adir I, Maayan G, Dahan O, Broday L, Pilpel Y, Rechavi O. (2016). Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes. PLoS Genet.

*Rechavi, O., Houri-Ze’evi, L., Anava, S., Goh, WS., Kerk, SY., Hannon, GJ., and Hobert, O.(2014). Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans. Cell. 

See also Leading Edge Commentary in Cell 

Rechavi, O. (2013). Guest list or black list: heritable small RNAs as immunogenic memories‏. Trends in Cell Biology. 

*Rechavi, O., Minevich, G., and Hobert, O. (2011). Transgenerational inheritance of an acquired small RNA-based antiviral response in C.elegans. Cell. 147, 1248 1256. 

See the F1000 Highlight

Rechavi, O., Kalman, M., Fang, Y., Vernitsky, H., Jacob-Hirsch, J., Foster, L. J., Kloog, Y., and Goldstein, I. (2010). Trans-SILAC: sorting out the non-cell-autonomous proteome. Nature Methods. 7:923-927. 

Rechavi, O., Erlich, Y., Amram, H., Flomenblit, L., Karginov, F. V., Goldstein, I, Hannon, G. J., and Kloog, Y. (2009). Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs. Genes & Development. 23:1971-1979.

* Corresponding author

 

 

Resources


Resources


 
 
 
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WorMachine: Machine Learning-Based Phenotypic Analysis Tool for Worms

A three-step MATLAB-based image analysis software developed in the Rechavi Lab that allows automated identification of C. elegans worms, extraction of morphological features, and quantification of fluorescent signals.


Planaria


Planaria


 
M Neuhof, M Levin, O Rechavi. (2016).  Vertically- and horizontally-transmitted memories – the fading boundaries between regeneration and inheritance in planaria.  Biology Open

M Neuhof, M Levin, O Rechavi. (2016). Vertically- and horizontally-transmitted memories – the fading boundaries between regeneration and inheritance in planaria. Biology Open

 
 
 

Funding


Funding


 
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The Zoo


The Zoo


Everything connects in the end!

We try very hard to let our curiosity guide us, and when the muse calls, we don’t get in its way. Because of that, we find ourselves studying many diverge subjects, including the mechanisms that allow toxoplasma parasites to control its host, translational read through, Pol III regulatory mechanisms, Ancient DNA, Fertility, Helmet formation in Daphnia, genome rearrangement in ciliates, polyploidy, development of new optogeneic tools,machine learning algorithms for automated phenotyping and decision making.